La capsaicina o capsicina és un alcaloide lipófilo de fórmula 8-metil-N-vanilil-6-nonenamida. És la substancia mayoritaria de un grupo de 14 que llaman capsicinoides que son las responsables del gusto picante de determinadas variedades de pimiento.
Clinical testing with Adlea has shown that a single administration (injection) of the compound into the knee can provide pain relief for weeks to months. This would offer an improvement over NSAIDs and COX-2 inhibitors which must be taken daily, may provide inadequate pain management and can cause sometimes serious side effects.
Injectable steroids are used to treat osteoarthritis of the knee, but have modest effects and may actually contribute to cartilage degeneration. Widely used hyaluronic acid products provide variable and modest patient response. Physicians are often reluctant to prescribe more potent opioid pain medications, due to the undesirable side effects of chronic use.
Adlea provides a treatment option that could potentially provide significant benefit by allowing patients to reduce the pain associated with moderate to severe OA for weeks or months, and restore quality of life by improving the function of their arthritic joint. For a subset of patients in their 40’s and 50’s, Adlea may also provide the option of delaying total knee replacement until later in life to prevent the artificial joint from wearing out and the subsequent need for additional intervention.
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